Explosm!

Specifically Cyanide and Happiness! A very well known comic, and rightfully so. It's all hilarious one-shots, usually using clever anti-jokes or play on words.

Main Site: Explosm

Brentafloss

I actually just discovered this recently, and if you're a video gamer this comic certainly is for you.

DYAC

Sure iPhones are popular out there, bringing all the marvels it has to offer into vivid light. But what about its mistakes? More importantly, what about its funny mistakes??? Well there's Damnyouautocorrect for that, showing all the hilarities that ensue when trying to deal with the iPhone's finicky auto correct feature.

Famous YouTuber...

...Ray William Johnson! I'm sure most of you have already heard of him and are even subscribed to his channel, but for those that aren't take a gander, even if you don't like him he finds many viral videos every week just for you.

Comic Combo!

Just rollin' out the comics now! Our next one is Boxer Hockey, with nice funny characters well infused. Although this has a rather slow update rate, it has a nice lengthy story, with comics focused on the story rather than humorous one-shots.

Source: Boxer Hockey

Note: Don't forget to tell your friends about this! The more people the merrier!